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UniProt functional annotation for P0A8P1 | ||
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| UniProt code: P0A8P1. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl- tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine. |
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| Catalytic activity: | |
Reaction=L-leucyl-tRNA(Leu) + N-terminal L-lysyl-[protein] = H(+) + N- terminal L-leucyl-L-lysyl-[protein] + tRNA(Leu); Xref=Rhea:RHEA:12340, Rhea:RHEA-COMP:9613, Rhea:RHEA-COMP:9622, Rhea:RHEA-COMP:12670, Rhea:RHEA-COMP:12671, ChEBI:CHEBI:15378, ChEBI:CHEBI:65249, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:133043; EC=2.3.2.6; |
| Catalytic activity: | |
Reaction=L-leucyl-tRNA(Leu) + N-terminal L-arginyl-[protein] = H(+) + N-terminal L-leucyl-L-arginyl-[protein] + tRNA(Leu); Xref=Rhea:RHEA:50416, Rhea:RHEA-COMP:9613, Rhea:RHEA-COMP:9622, Rhea:RHEA-COMP:12672, Rhea:RHEA-COMP:12673, ChEBI:CHEBI:15378, ChEBI:CHEBI:64719, ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:133044; EC=2.3.2.6; |
| Catalytic activity: | |
Reaction=an N-terminal L-alpha-aminoacyl-[protein] + L-phenylalanyl- tRNA(Phe) = an N-terminal L-phenylalanyl-L-alpha-aminoacyl-[protein] + tRNA(Phe); Xref=Rhea:RHEA:43632, Rhea:RHEA-COMP:9668, Rhea:RHEA- COMP:9699, Rhea:RHEA-COMP:10636, Rhea:RHEA-COMP:10637, ChEBI:CHEBI:78442, ChEBI:CHEBI:78531, ChEBI:CHEBI:78597, ChEBI:CHEBI:83561; EC=2.3.2.6; |
| Subunit: | |
Monomer. |
| Subcellular location: | |
Cytoplasm. |
| Similarity: | |
Belongs to the L/F-transferase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.