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UniProt functional annotation for O14776 | ||
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| UniProt code: O14776. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. {ECO:0000269|PubMed:11604498, ECO:0000269|PubMed:9315662}. |
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| Subunit: | |
Binds formin (By similarity). Interacts (via the second WW domain) with TREX1 (via proline-rich region) (By similarity). Binds RNA polymerase II, HD and SF1. {ECO:0000250, ECO:0000269|PubMed:10908677, ECO:0000269|PubMed:11172033, ECO:0000269|PubMed:11604498, ECO:0000269|PubMed:15485897, ECO:0000269|PubMed:9315662}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:10908677, ECO:0000269|PubMed:15485897, ECO:0000269|PubMed:9315662}. |
| Tissue specificity: | |
Detected in brain neurons. {ECO:0000269|PubMed:11172033}. |
| Induction: | |
Up-regulated in brain tissue from patients with Huntington disease. {ECO:0000269|PubMed:11172033}. |
| Domain: | |
The FF domains bind the phosphorylated C-terminus of the largest subunit of RNA polymerase II, probably mediate interaction with HTATSF1 and preferentially bind peptides with the consensus sequence [DE](2-5)-[FWY]-[DE](2-5). |
| Domain: | |
The WW domains bind Pro-rich domains. |
| Sequence caution: | |
Sequence=BAD93147.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.