UniProt functional annotation for Q8N6W0



	UniProt functional annotation for Q8N6W0

UniProt code: Q8N6W0.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269|PubMed:11158314}.

Subcellular location: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.

Tissue specificity: Expressed in brain. {ECO:0000269|PubMed:11158314}.

Similarity: Belongs to the CELF/BRUNOL family. {ECO:0000305}.

Sequence caution: Sequence=AAC27666.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07476.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAD92304.1; Type=Erroneous initiation; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre- mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. {ECO:0000269\|PubMed:11158314}.


Subcellular location:		Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
Tissue specificity:		Expressed in brain. {ECO:0000269\|PubMed:11158314}.
Similarity:		Belongs to the CELF/BRUNOL family. {ECO:0000305}.
Sequence caution:		Sequence=AAC27666.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07476.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305}; Sequence=BAD92304.1; Type=Erroneous initiation; Evidence={ECO:0000305};