UniProt functional annotation for Q9HAP6



	UniProt functional annotation for Q9HAP6

UniProt code: Q9HAP6.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta- catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O88951, ECO:0000269|PubMed:11742811}.

Subunit: Forms a complex with CASK and CASKIN1 (By similarity). Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2- LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (By similarity). Forms a heterotrimeric complex composed of MMP5, LIN7B and PATJ; the N-terminal L27 domain of PALS1 interacts with the L27 domain of PATJ and the C-terminal L27 domain of PALS1 interacts with the L27 domain of LIN7B (By similarity). Forms a heterotrimeric complex with DLG1 and CASK via their L27 domains (PubMed:11742811, PubMed:17237226). Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain (PubMed:11742811). The association of LIN7A with cadherin and beta- catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains (PubMed:12967566). Associates with KIF17 via APBA1 (By similarity). Interacts with ASIC3 (PubMed:15317815). Interacts with TOPK. Interacts with RTKN (PubMed:16979770). Interacts with APBA1 (By similarity). Interacts with MPP7 (PubMed:17237226). Interacts with DLG2 (By similarity). Interacts with DLG3 (By similarity). {ECO:0000250|UniProtKB:O88951, ECO:0000250|UniProtKB:Q9Z252, ECO:0000269|PubMed:11742811, ECO:0000269|PubMed:12967566, ECO:0000269|PubMed:15317815, ECO:0000269|PubMed:16979770, ECO:0000269|PubMed:17237226}.

Subcellular location: Cell membrane {ECO:0000250|UniProtKB:O88951}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Basolateral cell membrane {ECO:0000269|PubMed:11742811, ECO:0000269|PubMed:12967566}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Cell junction {ECO:0000250|UniProtKB:O88951}. Cell junction, synapse, postsynaptic density membrane {ECO:0000250|UniProtKB:O88951}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88951}. Cell junction, tight junction {ECO:0000250|UniProtKB:O88951}. Note=Mainly basolateral in renal epithelial cells. {ECO:0000269|PubMed:11742811}.

Domain: The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane. {ECO:0000250}.

Domain: The PDZ domain regulates endocytosis and recycling of the receptor at the membrane. {ECO:0000250}.

Domain: The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes. {ECO:0000250}.

Similarity: Belongs to the lin-7 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta- catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ASIC3 acid-evoked currents by stabilizing the channel at the cell surface (By similarity). {ECO:0000250, ECO:0000250\|UniProtKB:O88951, ECO:0000269\|PubMed:11742811}.


Subunit:		Forms a complex with CASK and CASKIN1 (By similarity). Component of the brain-specific heterotrimeric complex (LIN-10-LIN-2- LIN-7 complex) composed of at least APBA1, CASK, and LIN7, which associates with the motor protein KIF17 to transport vesicles along microtubules (By similarity). Forms a heterotrimeric complex composed of MMP5, LIN7B and PATJ; the N-terminal L27 domain of PALS1 interacts with the L27 domain of PATJ and the C-terminal L27 domain of PALS1 interacts with the L27 domain of LIN7B (By similarity). Forms a heterotrimeric complex with DLG1 and CASK via their L27 domains (PubMed:11742811, PubMed:17237226). Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain (PubMed:11742811). The association of LIN7A with cadherin and beta- catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains (PubMed:12967566). Associates with KIF17 via APBA1 (By similarity). Interacts with ASIC3 (PubMed:15317815). Interacts with TOPK. Interacts with RTKN (PubMed:16979770). Interacts with APBA1 (By similarity). Interacts with MPP7 (PubMed:17237226). Interacts with DLG2 (By similarity). Interacts with DLG3 (By similarity). {ECO:0000250\|UniProtKB:O88951, ECO:0000250\|UniProtKB:Q9Z252, ECO:0000269\|PubMed:11742811, ECO:0000269\|PubMed:12967566, ECO:0000269\|PubMed:15317815, ECO:0000269\|PubMed:16979770, ECO:0000269\|PubMed:17237226}.
Subcellular location:		Cell membrane {ECO:0000250\|UniProtKB:O88951}; Peripheral membrane protein {ECO:0000250\|UniProtKB:O88951}. Basolateral cell membrane {ECO:0000269\|PubMed:11742811, ECO:0000269\|PubMed:12967566}; Peripheral membrane protein {ECO:0000250\|UniProtKB:O88951}. Cell junction {ECO:0000250\|UniProtKB:O88951}. Cell junction, synapse, postsynaptic density membrane {ECO:0000250\|UniProtKB:O88951}; Peripheral membrane protein {ECO:0000250\|UniProtKB:O88951}. Cell junction, tight junction {ECO:0000250\|UniProtKB:O88951}. Note=Mainly basolateral in renal epithelial cells. {ECO:0000269\|PubMed:11742811}.
Domain:		The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane. {ECO:0000250}.
Domain:		The PDZ domain regulates endocytosis and recycling of the receptor at the membrane. {ECO:0000250}.
Domain:		The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes. {ECO:0000250}.
Similarity:		Belongs to the lin-7 family. {ECO:0000305}.