PDBsum entry 2dht

Oxidoreductase

PDB id: 2dht

Contents

Protein chains

403 a.a. *

Waters ×38

* Residue conservation analysis

PDB id:

2dht

Name:

Oxidoreductase

Title:

Crystal structure of isocitrate dehydrogenase from sulfolobus tokodaii strain7

Structure:

409aa long hypothetical NADP-dependent isocitrate dehydrogenase. Chain: a, b. Synonym: isocitrate dehydrogenase. Engineered: yes

Source:

Sulfolobus tokodaii. Organism_taxid: 273063. Strain: str. 7. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.50Å R-factor: 0.241 R-free: 0.272

Authors:

H.Kondo,M.Murakami,K.Ihara,S.Suzuki,T.Kouyama

Key ref:

H.Kondo et al. Crystal structure of isocitrate dehydrogenase of sulfolobus tokodaii strain7. To be published, .

Date:

25-Mar-06 Release date: 27-Mar-07

Protein chains

Q96YK6  (Q96YK6_SULTO) -  isocitrate dehydrogenase (NADP(+)) from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)

Seq: 409 a.a.

Struc: 403 a.a.

Enzyme reactions

• Enzyme class: E.C.1.1.1.42 - isocitrate dehydrogenase (NADP(+)).
• Pathway: Citric acid cycle
• Reaction: D-threo-isocitrate + NADP⁺ = 2-oxoglutarate + CO2 + NADPH
• Cofactor: Mn(2+) or Mg(2+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site