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UniProt functional annotation for P11889 | ||
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| UniProt code: P11889. |
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| Organism: | |
Bacillus cereus. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus; Bacillus cereus group. |
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| Function: | |
Required, with sphingomyelinase, to effect target cell lysis (hemolysis). |
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| Catalytic activity: | |
Reaction=a sphingomyelin + H2O = an N-acylsphing-4-enine + H(+) + phosphocholine; Xref=Rhea:RHEA:19253, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:17636, ChEBI:CHEBI:52639, ChEBI:CHEBI:295975; EC=3.1.4.12; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| Activity regulation: | |
Activated by cobalt and manganese ions. |
| Subcellular location: | |
Secreted. |
| Similarity: | |
Belongs to the neutral sphingomyelinase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.