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PDBsum entry 2dde
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References listed in PDB file
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Key reference
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Title
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Structure determination of an immunopotentiator peptide, Cinnamycin, Complexed with lysophosphatidylethanolamine by 1h-Nmr1.
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Authors
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K.Hosoda,
M.Ohya,
T.Kohno,
T.Maeda,
S.Endo,
K.Wakamatsu.
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Ref.
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J Biochem (tokyo), 1996,
119,
226-230.
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PubMed id
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Abstract
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The three-dimensional structure of a complex of cinnamycin, a 19-amino acid
residue immunopotentiator peptide, and lysophosphatidylethanolamine was
determined by 1H-NMR. The complex was cylindrical in shape, 11 A in diameter and
26 A in length, excluding the acyl chain of the phospholipid. The peptide had a
hydrophobic pocket surrounded by residues Phe-7 through Ala(S)-14 to bind to the
head group of the ligand. Fitting of the head group to the hydrophobic pocket
was so good that other than a glycerophosphoethanolamine head group would be
unable to fit the pocket. The goodness of the fitting is compatible with the
strict specificity of ligand binding of the peptide.
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