|
|
||
|
|
|
|
|
UniProt functional annotation for Q9H4I2 | ||
|
|
|
|
|
|
||
| UniProt code: Q9H4I2. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Acts as a transcriptional repressor. Involved in the early stages of mesenchymal stem cell (MSC) osteogenic differentiation. Is a regulator of podocyte gene expression during primary glomerula disease. Binds to promoter DNA. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. |
|
||
| Subunit: | |
Homodimer (via homeobox domain 1) (PubMed:12659632, PubMed:14659886). Heterodimer with ZHX1 (via homeobox domain 1) (PubMed:12659632). Heterodimer with ZHX2 (via homeobox domain 1) (PubMed:14659886). Heterodimerization with ZHX1 is a prerequisite for repressor activity (PubMed:12659632). Interacts with NFYA (PubMed:12659632). {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:14659886}. |
| Subcellular location: | |
Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12659632}. |
| Tissue specificity: | |
Widely expressed. High expression in kidney. Expressed during osteogenic differentiation. {ECO:0000269|PubMed:12659632, ECO:0000269|PubMed:21174497}. |
| Induction: | |
Up-regulated during osteogenic differentiation of mesenchymal stem cells. {ECO:0000269|PubMed:21174497}. |
| Similarity: | |
Belongs to the ZHX family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAA23691.3; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.