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UniProt functional annotation for P09919 | ||
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| UniProt code: P09919. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes. |
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| Subunit: | |
Monomer. {ECO:0000269|PubMed:10537111, ECO:0000269|PubMed:16492764}. |
| Subcellular location: | |
Secreted. |
| Ptm: | |
O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G- CSF from CHO cells). |
| Pharmaceutical: | |
Available under the names Neupogen or Granulokine (Amgen/Roche) and Granocyte (Rhone-Poulenc). Used to treat neutropenia (a disorder characterized by an extremely low number of neutrophils in blood). |
| Similarity: | |
Belongs to the IL-6 superfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.