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UniProt functional annotation for Q58VP7 | ||
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| UniProt code: Q58VP7. |
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| Organism: | |
Aloe arborescens (Kidachi aloe). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Asphodelaceae; Asphodeloideae; Aloe. |
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| Function: | |
Catalyzes the iterative condensations of 5 molecules of malonyl-CoA to produce a pentaketide 5,7-dihydroxy-2-methylchromone. {ECO:0000269|PubMed:15686354}. |
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| Catalytic activity: | |
Reaction=4 H(+) + 5 malonyl-CoA = 5,7-dihydroxy-2-methyl-4H-chromen-4- one + 5 CO2 + 5 CoA + H2O; Xref=Rhea:RHEA:34839, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:57287, ChEBI:CHEBI:57384, ChEBI:CHEBI:77977; EC=2.3.1.216; Evidence={ECO:0000269|PubMed:15686354}; |
| Biophysicochemical properties: | |
Kinetic parameters: KM=71 uM for malonyl-CoA {ECO:0000269|PubMed:15686354}; Note=Kcat is 0.445 min(-1).; pH dependence: Optimum pH is 6.0-8.0. {ECO:0000269|PubMed:15686354}; |
| Pathway: | |
Secondary metabolite biosynthesis; flavonoid biosynthesis. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:15686354, ECO:0000269|PubMed:17462571}. |
| Miscellaneous: | |
A.arborescens is a medicinal plant rich in aromatic polyketides, such as pharmaceutically important aloenin (hexaketide), aloesin (heptaketide) and barbaloin (octaketide). |
| Similarity: | |
Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.