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UniProt functional annotation for P68261 | ||
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| UniProt code: P68261. |
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| Organism: | |
Staphylococcus aureus (strain N315). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. |
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| Function: | |
Transcriptional repressor that constitutively blocks the transcription of the gene for the penicillin-binding protein MecA. Binds palindromic DNA with the sequence 5'-TACA-[AT]-N-TGTA-3'. Regulates genes involved in antibiotic resistance. Binds DNA as a dimer. |
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| Subunit: | |
Monomer and homodimer. {ECO:0000269|PubMed:12881514, ECO:0000269|PubMed:14960592, ECO:0000269|PubMed:16582476}. |
| Subcellular location: | |
Cytoplasm {ECO:0000305}. |
| Ptm: | |
Upon exposure to beta-lactams, proteolytic cleavage at a single site impairs dimerization and abolishes repressor activity. {ECO:0000250}. |
| Similarity: | |
Belongs to the BlaI transcriptional regulatory family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.