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UniProt functional annotation for Q6L6Q4 | ||
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| UniProt code: Q6L6Q4. |
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| Organism: | |
Geobacillus stearothermophilus (Bacillus stearothermophilus). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus. |
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| Function: | |
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. {ECO:0000256|ARBA:ARBA00004065, ECO:0000256|HAMAP- Rule:MF_00053}. |
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| Catalytic activity: | |
Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4; Evidence={ECO:0000256|ARBA:ARBA00000077, ECO:0000256|HAMAP- Rule:MF_00053}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|ARBA:ARBA00001946}; |
| Cofactor: | |
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|ARBA:ARBA00001936}; |
| Cofactor: | |
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000256|HAMAP-Rule:MF_00053}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000256|HAMAP-Rule:MF_00053}; Note=Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. {ECO:0000256|HAMAP-Rule:MF_00053}; |
| Subcellular location: | |
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00053}. |
| Similarity: | |
Belongs to the RNase HII family. RnhC subfamily. {ECO:0000256|ARBA:ARBA00008378, ECO:0000256|HAMAP-Rule:MF_00053}. |
Annotations taken from UniProtKB at the EBI.