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UniProt functional annotation for P06745 | ||
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| UniProt code: P06745. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
In the cytoplasm, catalyzes the conversion of glucose-6- phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (PubMed:7277315, PubMed:2344351, PubMed:8417789). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility (By similarity). Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons (PubMed:3764429, PubMed:3352745). It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (PubMed:3352745). {ECO:0000250|UniProtKB:P06744, ECO:0000269|PubMed:2344351, ECO:0000269|PubMed:3352745, ECO:0000269|PubMed:3764429, ECO:0000269|PubMed:7277315, ECO:0000269|PubMed:8417789}. |
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| Catalytic activity: | |
Reaction=aldehydo-D-glucose 6-phosphate = keto-D-fructose 6-phosphate; Xref=Rhea:RHEA:11816, ChEBI:CHEBI:57579, ChEBI:CHEBI:57584; EC=5.3.1.9; Evidence={ECO:0000269|PubMed:2344351, ECO:0000269|PubMed:8417789}; |
| Pathway: | |
Carbohydrate degradation; glycolysis; D-glyceraldehyde 3- phosphate and glycerone phosphate from D-glucose: step 2/4. {ECO:0000269|PubMed:2344351, ECO:0000269|PubMed:7277315, ECO:0000269|PubMed:8417789}. |
| Subunit: | |
Homodimer in the catalytically active form, monomer in the secreted form. {ECO:0000269|PubMed:15342241, ECO:0000269|PubMed:16375918, ECO:0000269|PubMed:2344351}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250|UniProtKB:P06744}. Secreted {ECO:0000250|UniProtKB:P06744}. |
| Ptm: | |
ISGylated. {ECO:0000269|PubMed:16139798}. |
| Disruption phenotype: | |
Embryonic lethality caused by impaired gastrulation (PubMed:8922529). During early development, the egg cylinder fails to be divided into the three cavities, suggesting a deficiency in extraembryonic mesoderm formation resulting in the failure to form the amnion or chorionic mesoderm (PubMed:8922529). {ECO:0000269|PubMed:8922529}. |
| Similarity: | |
Belongs to the GPI family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAC36335.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.