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UniProt functional annotation for Q96JZ2 | ||
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| UniProt code: Q96JZ2. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}. |
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| Subunit: | |
Interacts with FES and TNK2. {ECO:0000269|PubMed:11700021}. |
| Subcellular location: | |
Cytoplasm. Nucleus. |
| Tissue specificity: | |
Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta. {ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172}. |
| Ptm: | |
May be phosphorylated by FES and ACK1. {ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:15284240}. |
Annotations taken from UniProtKB at the EBI.