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UniProt functional annotation for P62995 | ||
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| UniProt code: P62995. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. {ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:12761049, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:9546399}. |
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| Subunit: | |
Interacts with SAFB/SAFB1 (By similarity). Found in a pre-mRNA exonic splicing enhancer (ESE) complex with TRA2B/SFRS10, SNRNP70, SNRPA1 and SRRM1. Binds to A3 enhancer proteins SFRS4, SFRS5, SFRS6 and SFRS9. Interacts with CPSF6, RBMY1A1, RBMX, RNPS1 and phosphorylated SFRS13A. {ECO:0000250, ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10749975, ECO:0000269|PubMed:12165565, ECO:0000269|PubMed:14729963, ECO:0000269|PubMed:14765198, ECO:0000269|PubMed:15169763, ECO:0000269|PubMed:19282290}. |
| Subcellular location: | |
Nucleus {ECO:0000269|PubMed:9212162, ECO:0000269|PubMed:9546399}. |
| Tissue specificity: | |
Highest expression in heart, skeletal muscle and pancreas. Less abundant in kidney, placenta and brain. Lowest expression in kidney and liver. {ECO:0000269|PubMed:9790768}. |
| Ptm: | |
Phosphorylated in the RS domains. {ECO:0000269|PubMed:9546399}. |
| Ptm: | |
Dimethylation at Arg-241 is probably asymmetric. |
| Similarity: | |
Belongs to the splicing factor SR family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.