UniProt functional annotation for P59636



	UniProt functional annotation for P59636

UniProt code: P59636.

Organism: Severe acute respiratory syndrome coronavirus (SARS-CoV).

Taxonomy: Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus.

Function: Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin- like protein 1/DNM1L. {ECO:0000269|PubMed:25135833}.

Subunit: Homodimer. Interacts with host XPO1; this interaction mediates protein ORF9b export out of the nucleus (PubMed:21637748). Interacts with host MAVS (PubMed:25135833). Interacts with protein ORF6 (PubMed:22820404). {ECO:0000269|PubMed:21637748, ECO:0000269|PubMed:22820404, ECO:0000269|PubMed:25135833}.

Subcellular location: Virion {ECO:0000269|PubMed:19394665}. Host cytoplasmic vesicle membrane {ECO:0000269|PubMed:16843897}; Peripheral membrane protein {ECO:0000269|PubMed:16843897}. Host cytoplasm {ECO:0000269|PubMed:16843897, ECO:0000269|PubMed:21637748, ECO:0000269|PubMed:22820404}. Host endoplasmic reticulum {ECO:0000269|PubMed:17448558}. Host nucleus {ECO:0000269|PubMed:21637748}. Host mitochondrion {ECO:0000269|PubMed:25135833}. Note=Binds non-covalently to intracellular lipid bilayers.

Miscellaneous: The gene encoding this protein is included within the N gene (alternative ORF).

Similarity: Belongs to the coronavirus group 2 protein 9b family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Severe acute respiratory syndrome coronavirus (SARS-CoV).
Taxonomy:		Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus.



Function:		Plays a role in the inhibition of host innate immune response by targeting the mitochondrial-associated adapter MAVS. Mechanistically, usurps the E3 ligase ITCH to trigger the degradation of MAVS, TRAF3, and TRAF6. In addition, causes mitochondrial elongation by triggering ubiquitination and proteasomal degradation of dynamin- like protein 1/DNM1L. {ECO:0000269\|PubMed:25135833}.


Subunit:		Homodimer. Interacts with host XPO1; this interaction mediates protein ORF9b export out of the nucleus (PubMed:21637748). Interacts with host MAVS (PubMed:25135833). Interacts with protein ORF6 (PubMed:22820404). {ECO:0000269\|PubMed:21637748, ECO:0000269\|PubMed:22820404, ECO:0000269\|PubMed:25135833}.
Subcellular location:		Virion {ECO:0000269\|PubMed:19394665}. Host cytoplasmic vesicle membrane {ECO:0000269\|PubMed:16843897}; Peripheral membrane protein {ECO:0000269\|PubMed:16843897}. Host cytoplasm {ECO:0000269\|PubMed:16843897, ECO:0000269\|PubMed:21637748, ECO:0000269\|PubMed:22820404}. Host endoplasmic reticulum {ECO:0000269\|PubMed:17448558}. Host nucleus {ECO:0000269\|PubMed:21637748}. Host mitochondrion {ECO:0000269\|PubMed:25135833}. Note=Binds non-covalently to intracellular lipid bilayers.
Miscellaneous:		The gene encoding this protein is included within the N gene (alternative ORF).
Similarity:		Belongs to the coronavirus group 2 protein 9b family. {ECO:0000305}.