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UniProt functional annotation for P59869 | ||
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| UniProt code: P59869. |
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| Organism: | |
Hottentotta tamulus (Eastern Indian scorpion) (Mesobuthus tamulus). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Mesobuthus. |
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| Function: | |
Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213). Induces cell death when tested on Jurkat E6-1 and human mammary breast cancer MDA-MB-231 which constituvely express KCa2.2/KCNN2, but not on human peripheral blood lymphocytes (which do not express KCa2.2/KCNN2) (PubMed:24821061). {ECO:0000269|PubMed:12239213}. |
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| Subcellular location: | |
Secreted {ECO:0000269|PubMed:12239213}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305|PubMed:12239213}. |
| Domain: | |
Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta). {ECO:0000269|PubMed:24821061}. |
| Mass spectrometry: | |
Mass=3457.9; Mass_error=0.2; Method=Electrospray; Evidence={ECO:0000269|PubMed:12239213}; |
| Miscellaneous: | |
Does not show inhibition on KCa3.1/KCNN4 at concentrations up to 50 nM. {ECO:0000269|PubMed:12239213}. |
| Similarity: | |
Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 05 subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.