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UniProt functional annotation for Q9WZ49 | ||
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| UniProt code: Q9WZ49. |
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| Organism: | |
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8). |
| Taxonomy: | |
Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga. |
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| Function: | |
Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins. {ECO:0000255|HAMAP- Rule:MF_01458}. |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000255|HAMAP-Rule:MF_01458, ECO:0000269|PubMed:16484367}; Note=Binds 1 zinc ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01458, ECO:0000269|PubMed:16484367}; |
| Subunit: | |
The isolated ADP-bound cytosolic domain forms a 6-fold symmetric protease disk and a 2-fold symmetric AAA ATPase ring. In the absence of nucleotide the AAA ATPase ring also forms symmetric hexamers. {ECO:0000269|PubMed:16484367, ECO:0000269|PubMed:19955424}. |
| Subcellular location: | |
Cell inner membrane {ECO:0000255|HAMAP- Rule:MF_01458}; Multi-pass membrane protein {ECO:0000255|HAMAP- Rule:MF_01458}; Cytoplasmic side {ECO:0000255|HAMAP-Rule:MF_01458}. |
| Similarity: | |
In the central section; belongs to the AAA ATPase family. {ECO:0000255|HAMAP-Rule:MF_01458}. |
| Similarity: | |
In the C-terminal section; belongs to the peptidase M41 family. {ECO:0000255|HAMAP-Rule:MF_01458}. |
Annotations taken from UniProtKB at the EBI.