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UniProt functional annotation for P10186 | ||
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| UniProt code: P10186. |
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| Organism: | |
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1). |
| Taxonomy: | |
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus. |
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| Function: | |
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or deamination of cytosines. Therefore may reduce deleterious uracil incorporation into the viral genome, particularly in terminally differentiated cells which lack DNA repair enzymes. {ECO:0000255|HAMAP- Rule:MF_04046, ECO:0000269|PubMed:16306042, ECO:0000269|PubMed:7552746, ECO:0000269|PubMed:8391260}. |
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| Catalytic activity: | |
Reaction=Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.27; Evidence={ECO:0000255|HAMAP-Rule:MF_04046, ECO:0000269|PubMed:8391260}; |
| Subcellular location: | |
Host nucleus {ECO:0000255|HAMAP-Rule:MF_04046, ECO:0000269|PubMed:8391260}. |
| Similarity: | |
Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. {ECO:0000255|HAMAP-Rule:MF_04046}. |
Annotations taken from UniProtKB at the EBI.