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UniProt functional annotation for P94692 | ||
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| UniProt code: P94692. |
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| Organism: | |
Desulfocurvibacter africanus (Desulfovibrio africanus). |
| Taxonomy: | |
Bacteria; Proteobacteria; Deltaproteobacteria; Desulfovibrionales; Desulfovibrionaceae; Desulfocurvibacter. |
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| Function: | |
Catalyzes the ferredoxin-dependent oxidative decarboxylation of pyruvate. Required for the transfer of electrons from pyruvate to ferredoxin (PubMed:9294422, PubMed:7612653). Ferredoxin I and ferredoxin II, which are single 4Fe-4S cluster ferredoxins are the most effective electron carriers of POR (PubMed:7612653). {ECO:0000269|PubMed:7612653}. |
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| Catalytic activity: | |
Reaction=CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]; Xref=Rhea:RHEA:12765, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288; EC=1.2.7.1; Evidence={ECO:0000269|PubMed:7612653}; |
| Cofactor: | |
Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000269|PubMed:10048931, ECO:0000269|PubMed:11752578, ECO:0000269|PubMed:16472741, ECO:0000269|PubMed:7612653}; Note=Binds 3 [4Fe-4S] clusters per subunit. {ECO:0000269|PubMed:10048931, ECO:0000269|PubMed:11752578, ECO:0000269|PubMed:16472741, ECO:0000269|PubMed:7612653}; |
| Cofactor: | |
Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000269|PubMed:10048931, ECO:0000269|PubMed:11752578, ECO:0000269|PubMed:16472741}; Note=Binds 1 thiamine pyrophosphate per subunit. {ECO:0000269|PubMed:10048931, ECO:0000269|PubMed:11752578, ECO:0000269|PubMed:16472741}; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:10048931, ECO:0000269|PubMed:11752578, ECO:0000269|PubMed:16472741}; Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000269|PubMed:10048931, ECO:0000269|PubMed:11752578, ECO:0000269|PubMed:16472741}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:10048931, ECO:0000269|PubMed:11752578, ECO:0000269|PubMed:16472741, ECO:0000269|PubMed:7612653}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:7612653}. |
| Similarity: | |
Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.