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UniProt functional annotation for Q8U122 | ||
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| UniProt code: Q8U122. |
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| Organism: | |
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1). |
| Taxonomy: | |
Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Pyrococcus. |
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| Function: | |
Catalyzes the reversible phosphorylation of UMP to UDP, with ATP as the most efficient phosphate donor. {ECO:0000269|PubMed:15698963}. |
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| Catalytic activity: | |
Reaction=ATP + UMP = ADP + UDP; Xref=Rhea:RHEA:24400, ChEBI:CHEBI:30616, ChEBI:CHEBI:57865, ChEBI:CHEBI:58223, ChEBI:CHEBI:456216; EC=2.7.4.22; |
| Activity regulation: | |
Inhibited by UTP. {ECO:0000250}. |
| Pathway: | |
Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1. |
| Subunit: | |
Homohexamer; trimer of dimers. {ECO:0000269|PubMed:16095620, ECO:0000269|Ref.4}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Similarity: | |
Belongs to the UMP kinase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.