UniProt functional annotation for Q9UHX3



	UniProt functional annotation for Q9UHX3

UniProt code: Q9UHX3.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242). {ECO:0000269|PubMed:12829604, ECO:0000269|PubMed:17928360, ECO:0000269|PubMed:22310662, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:26841242}.

Subunit: Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is calcium-dependent. Interacts with CD55. {ECO:0000269|PubMed:12829604, ECO:0000269|PubMed:15150276, ECO:0000269|PubMed:17449467}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:22310662, ECO:0000269|PubMed:26841242}; Multi-pass membrane protein. Cell projection, ruffle membrane {ECO:0000269|PubMed:17928360}; Multi-pass membrane protein. Note=Localized at the leading edge of migrating cells. {ECO:0000269|PubMed:17928360}.

Tissue specificity: Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. High expression in mast cells (PubMed:26841242). {ECO:0000269|PubMed:10903844, ECO:0000269|PubMed:11994511, ECO:0000269|PubMed:26841242}.

Domain: The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk. {ECO:0000269|PubMed:12860403}.

Domain: Binding to chondroitin sulfate is mediated by the fourth EGF domain.

Ptm: Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit. {ECO:0000269|PubMed:12860403}.

Disease: Vibratory urticaria (VBU) [MIM:125630]: An autosomal dominant disorder characterized by localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum. {ECO:0000269|PubMed:26841242}. Note=The disease is caused by variants affecting the gene represented in this entry.

Miscellaneous: Has no murine ortholog. {ECO:0000305}.

Similarity: Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.

Sequence caution: Sequence=BAC06146.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242). {ECO:0000269\|PubMed:12829604, ECO:0000269\|PubMed:17928360, ECO:0000269\|PubMed:22310662, ECO:0000269\|PubMed:22575658, ECO:0000269\|PubMed:26841242}.


Subunit:		Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate; the interaction with chondroitin sulfate is calcium-dependent. Interacts with CD55. {ECO:0000269\|PubMed:12829604, ECO:0000269\|PubMed:15150276, ECO:0000269\|PubMed:17449467}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:22310662, ECO:0000269\|PubMed:26841242}; Multi-pass membrane protein. Cell projection, ruffle membrane {ECO:0000269\|PubMed:17928360}; Multi-pass membrane protein. Note=Localized at the leading edge of migrating cells. {ECO:0000269\|PubMed:17928360}.
Tissue specificity:		Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, placenta, and lung, and no expression in heart, brain, skeletal muscle, kidney, or pancreas. Expression is also detected in monocyte/macrophage and Jurkat cell lines but not in other cell lines tested. High expression in mast cells (PubMed:26841242). {ECO:0000269\|PubMed:10903844, ECO:0000269\|PubMed:11994511, ECO:0000269\|PubMed:26841242}.
Domain:		The GPS domain is necessary, but not sufficient for receptor cleavage, which require the entire extracellular stalk. {ECO:0000269\|PubMed:12860403}.
Domain:		Binding to chondroitin sulfate is mediated by the fourth EGF domain.
Ptm:		Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane beta subunit. {ECO:0000269\|PubMed:12860403}.
Disease:		Vibratory urticaria (VBU) [MIM:125630]: An autosomal dominant disorder characterized by localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum. {ECO:0000269\|PubMed:26841242}. Note=The disease is caused by variants affecting the gene represented in this entry.
Miscellaneous:		Has no murine ortholog. {ECO:0000305}.
Similarity:		Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
Sequence caution:		Sequence=BAC06146.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};