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UniProt functional annotation for Q01782 | ||
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| UniProt code: Q01782. |
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| Organism: | |
Leishmania major. |
| Taxonomy: | |
Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina; Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania. |
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| Function: | |
Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX). {ECO:0000269|PubMed:7972081}. |
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| Catalytic activity: | |
Reaction=(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP(+) = 2 H(+) + L-erythro-biopterin + 2 NADPH; Xref=Rhea:RHEA:19509, ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:59560, ChEBI:CHEBI:63931; EC=1.5.1.33; |
| Pathway: | |
Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from biopterin: step 1/1. {ECO:0000269|PubMed:9521731}. |
| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:11373620, ECO:0000269|PubMed:9153248}. |
| Similarity: | |
Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.