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UniProt functional annotation for Q00459 | ||
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| UniProt code: Q00459. |
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| Organism: | |
Pseudomonas mendocina. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas. |
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| Function: | |
Effector component of the toluene-4-monooxygenase multicomponent enzyme system which catalyzes the O2- and NADH-dependent hydroxylation of toluene to form p-cresol (PubMed:1885512, PubMed:15240250, PubMed:11297417, PubMed:15882052, PubMed:19033467). Required for optimal efficiency and specificity of the holoenzyme (PubMed:15882052, PubMed:19033467). {ECO:0000269|PubMed:11297417, ECO:0000269|PubMed:15240250, ECO:0000269|PubMed:15882052, ECO:0000269|PubMed:1885512, ECO:0000269|PubMed:19033467}. |
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| Pathway: | |
Xenobiotic degradation; toluene degradation. {ECO:0000305|PubMed:15240250}. |
| Subunit: | |
The alkene monooxygenase multicomponent enzyme system is composed of an electron transfer component and a monooxygenase component interacting with the effector protein TmoD. The electron transfer component is composed of a ferredoxin reductase (TmoF) and a ferredoxin (TmoC), and the monooxygenase component is formed by a heterohexamer (dimer of heterotrimers) of two alpha subunits (TmoA), two beta subunits (TmoE) and two gamma subunits (TmoB). {ECO:0000269|PubMed:19033467, ECO:0000269|PubMed:19290655, ECO:0000269|PubMed:19705873, ECO:0000269|PubMed:22264099, ECO:0000269|PubMed:28346937}. |
| Disruption phenotype: | |
Cells lacking this gene show a complete loss of toluene-4-monooxygenase activity. {ECO:0000269|PubMed:1885512}. |
| Similarity: | |
Belongs to the TmoD/XamoD family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.