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UniProt functional annotation for P28068 | ||
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| UniProt code: P28068. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Plays a critical role in catalyzing the release of class II- associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}. |
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| Subunit: | |
Heterodimer of an alpha chain (DMA) and a beta chain (DMB) (PubMed:16547258, PubMed:9768757). Interacts with MHCII; this interaction mediates rapid selection of high-affinity peptides in a pH- dependent manner, with an optimum at pH 5.5 (PubMed:23260142). {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:9768757}. |
| Subcellular location: | |
Late endosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Lysosome membrane {ECO:0000269|PubMed:8757605}; Single-pass type I membrane protein {ECO:0000269|PubMed:8757605}. Note=Localizes to late endocytic compartment. Associates with lysosome membranes. |
| Domain: | |
The YXXZ (Tyr-Xaa-Xaa-Zaa, where Zaa is a hydrophobic residue) motif mediates the targeting to the lysosomal compartments. |
| Polymorphism: | |
The following alleles of DMB are known: DMB*01:01, DMB*01:02, DMB*01:03, DMB*01:04 (DMB3.4), DMB*01:05, DMB*01:06, and DMB*01:07. The sequence shown is that of DMB*01:01. |
| Similarity: | |
Belongs to the MHC class II family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.