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UniProt functional annotation for Q5XC60 | ||
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| UniProt code: Q5XC60. |
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| Organism: | |
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus. |
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| Function: | |
Catalyzes the four-electron reduction of molecular oxygen to water. {ECO:0000250|UniProtKB:P37061}. |
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| Catalytic activity: | |
Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; Evidence={ECO:0000250|UniProtKB:P37061}; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250|UniProtKB:P37062}; Note=Binds 1 FAD per subunit. {ECO:0000250|UniProtKB:P37062}; |
| Mass spectrometry: | |
Mass=49603.57; Method=Electrospray; Evidence={ECO:0000269|Ref.2}; |
| Miscellaneous: | |
The active site is the redox-active Cys-44 oxidized to Cys-SOH. The oxidized form is stabilized by a hydrogen bond formation with His-11 (By similarity). {ECO:0000250}. |
| Similarity: | |
Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family. {ECO:0000255}. |
Annotations taken from UniProtKB at the EBI.