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UniProt functional annotation for Q9WDA7 | ||
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| UniProt code: Q9WDA7. |
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| Organism: | |
Dengue virus 2. |
| Taxonomy: | |
Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes; Amarillovirales; Flaviviridae; Flavivirus. |
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| Function: | |
Functions as a signal peptide for NS4B and is required for the interferon antagonism activity of the latter. {ECO:0000256|ARBA:ARBA00003504}. |
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| Function: | |
Serine protease subunit NS2B: Required cofactor for the serine protease function of NS3. {ECO:0000256|PROSITE- ProRule:PRU00859}. |
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| Catalytic activity: | |
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13; Evidence={ECO:0000256|ARBA:ARBA00001556}; |
| Catalytic activity: | |
Reaction=a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'- diphosphate + H(+) + phosphate; Xref=Rhea:RHEA:23680, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:57930, ChEBI:CHEBI:61557; EC=3.6.1.15; Evidence={ECO:0000256|ARBA:ARBA00001491}; |
| Subcellular location: | |
Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004477}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004397}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004397}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004397}. Endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004367}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004367}; Lumenal side {ECO:0000256|ARBA:ARBA00004367}. Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004153}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004153}. Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00004461}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004461}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004461}. Host endoplasmic reticulum membrane {ECO:0000256|ARBA:ARBA00023443}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00023443}; Lumenal side {ECO:0000256|ARBA:ARBA00023443}. Host nucleus {ECO:0000256|ARBA:ARBA00004147}. Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}. Nucleus {ECO:0000256|ARBA:ARBA00004123}. Secreted {ECO:0000256|ARBA:ARBA00004613}. Virion {ECO:0000256|ARBA:ARBA00004328}. Virion membrane {ECO:0000256|ARBA:ARBA00004385}; Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004385}. |
Annotations taken from UniProtKB at the EBI.