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UniProt functional annotation for P17967 | ||
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| UniProt code: P17967. |
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| Organism: | |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces. |
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| Function: | |
Protein disulfide isomerase of ER lumen required for formation of disulfide bonds in secretory and cell-surface proteins and which unscrambles non-native disulfide bonds. Forms a complex with MNL1 to process unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2, promoting degradation in unfolded protein response. {ECO:0000269|PubMed:16002399, ECO:0000269|PubMed:19124653, ECO:0000269|PubMed:21700223}. |
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| Catalytic activity: | |
Reaction=Catalyzes the rearrangement of -S-S- bonds in proteins.; EC=5.3.4.1; |
| Subunit: | |
Interacts with EPS1, KAR2 and MNL1. {ECO:0000269|PubMed:16002399, ECO:0000269|PubMed:19124653, ECO:0000269|PubMed:21700223}. |
| Subcellular location: | |
Endoplasmic reticulum lumen {ECO:0000255|PROSITE- ProRule:PRU10138}. |
| Ptm: | |
The N-terminus is blocked. |
| Similarity: | |
Belongs to the protein disulfide isomerase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.