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PDBsum entry 2b0s
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Immune system
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PDB id
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2b0s
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Contents |
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215 a.a.
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226 a.a.
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16 a.a.
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References listed in PDB file
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Key reference
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Title
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Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different v3 peptides reveal a new binding mode for HIV-1 cross-Reactivity.
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Authors
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R.L.Stanfield,
M.K.Gorny,
S.Zolla-Pazner,
I.A.Wilson.
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Ref.
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J Virol, 2006,
80,
6093-6105.
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PubMed id
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Abstract
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Human monoclonal antibody 2219 is a neutralizing antibody isolated from a human
immunodeficiency virus type 1-infected individual. 2219 was originally selected
for binding to a V3 fusion protein and can neutralize primary isolates from
subtypes B, A, and F. Thus, 2219 represents a cross-reactive, human anti-V3
antibody. Fab 2219 binds to one face of the variable V3 beta-hairpin, primarily
contacting conserved residues on the N-terminal beta-strand of V3, leaving the
V3 crown or tip largely accessible. Three V3/2219 complexes reveal the
antibody-bound conformations for both the N- and C-terminal regions that flank
the V3 crown and illustrate how twisting of the V3 loop alters the relative
dispositions and pairing of the amino acids in the adjacent V3 beta-strands and
how the antibody can accommodate V3 loops with different sequences.
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