UniProt functional annotation for P02359



	UniProt functional annotation for P02359

UniProt code: P02359.

Organism: Escherichia coli (strain K12).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.

Function: One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit (PubMed:2461734). Is located at the subunit interface close to the decoding center, where it has been shown to contact mRNA (PubMed:10606263). Has been shown to contact tRNA in both the P and E sites; it probably blocks exit of the E site tRNA (PubMed:8524654). {ECO:0000269|PubMed:10606263, ECO:0000269|PubMed:2461734, ECO:0000269|PubMed:8524654}.

Function: Protein S7 is also a translational repressor protein; it regulates the expression of the str operon members to different degrees by binding to its mRNA. {ECO:0000269|PubMed:7507167}.

Subunit: Part of the 30S ribosomal subunit (PubMed:385062, PubMed:7556101, PubMed:10094780, PubMed:12809609, PubMed:16272117, PubMed:27934701, PubMed:12244297, PubMed:27906160, PubMed:27906161, PubMed:28077875). Contacts proteins S9 and S11 (By similarity). Cross- links to IF3 and the P and E site tRNAs (PubMed:7000779, PubMed:6349681, PubMed:8524654). {ECO:0000250|UniProtKB:P17291, ECO:0000269|PubMed:10094780, ECO:0000269|PubMed:12244297, ECO:0000269|PubMed:12809609, ECO:0000269|PubMed:16272117, ECO:0000269|PubMed:27906160, ECO:0000269|PubMed:27906161, ECO:0000269|PubMed:27934701, ECO:0000269|PubMed:28077875, ECO:0000269|PubMed:385062, ECO:0000269|PubMed:7556101, ECO:0000269|PubMed:8524654, ECO:0000305|PubMed:6349681, ECO:0000305|PubMed:7000779}.

Mass spectrometry: Mass=19888.7; Method=MALDI; Evidence={ECO:0000269|PubMed:10094780};

Miscellaneous: The strain K12 sequence is shown.

Miscellaneous: Has been predicted to contact the N-terminal domain of IF-3 based on footprint studies; exactly how IF-3 interacts with the 30S subunit is controversial (PubMed:7000779, PubMed:6349681, PubMed:11684020). {ECO:0000305|PubMed:11684020, ECO:0000305|PubMed:6349681, ECO:0000305|PubMed:7000779}.

Similarity: Belongs to the universal ribosomal protein uS7 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Escherichia coli (strain K12).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.



Function:		One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit (PubMed:2461734). Is located at the subunit interface close to the decoding center, where it has been shown to contact mRNA (PubMed:10606263). Has been shown to contact tRNA in both the P and E sites; it probably blocks exit of the E site tRNA (PubMed:8524654). {ECO:0000269\|PubMed:10606263, ECO:0000269\|PubMed:2461734, ECO:0000269\|PubMed:8524654}.



Function:		Protein S7 is also a translational repressor protein; it regulates the expression of the str operon members to different degrees by binding to its mRNA. {ECO:0000269\|PubMed:7507167}.


Subunit:		Part of the 30S ribosomal subunit (PubMed:385062, PubMed:7556101, PubMed:10094780, PubMed:12809609, PubMed:16272117, PubMed:27934701, PubMed:12244297, PubMed:27906160, PubMed:27906161, PubMed:28077875). Contacts proteins S9 and S11 (By similarity). Cross- links to IF3 and the P and E site tRNAs (PubMed:7000779, PubMed:6349681, PubMed:8524654). {ECO:0000250\|UniProtKB:P17291, ECO:0000269\|PubMed:10094780, ECO:0000269\|PubMed:12244297, ECO:0000269\|PubMed:12809609, ECO:0000269\|PubMed:16272117, ECO:0000269\|PubMed:27906160, ECO:0000269\|PubMed:27906161, ECO:0000269\|PubMed:27934701, ECO:0000269\|PubMed:28077875, ECO:0000269\|PubMed:385062, ECO:0000269\|PubMed:7556101, ECO:0000269\|PubMed:8524654, ECO:0000305\|PubMed:6349681, ECO:0000305\|PubMed:7000779}.
Mass spectrometry:		Mass=19888.7; Method=MALDI; Evidence={ECO:0000269\|PubMed:10094780};
Miscellaneous:		The strain K12 sequence is shown.
Miscellaneous:		Has been predicted to contact the N-terminal domain of IF-3 based on footprint studies; exactly how IF-3 interacts with the 30S subunit is controversial (PubMed:7000779, PubMed:6349681, PubMed:11684020). {ECO:0000305\|PubMed:11684020, ECO:0000305\|PubMed:6349681, ECO:0000305\|PubMed:7000779}.
Similarity:		Belongs to the universal ribosomal protein uS7 family. {ECO:0000305}.