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UniProt functional annotation for P9WLL7 | ||
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| UniProt code: P9WLL7. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Catalyzes the F420H(2)-dependent reduction of biliverdin- IXalpha at C10 position, leading to bilirubin-IXalpha, a potent antioxidant. As biliverdin-IXalpha is produced in high amounts in macrophages infected with M.tuberculosis, its reduction by Rv2074 may play a role in protecting mycobacteria against oxidative stress, aiding the persistence of M.tuberculosis infection. {ECO:0000269|PubMed:27364382}. |
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| Catalytic activity: | |
Reaction=bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma- Glu)(n) = biliverdin IXalpha + reduced coenzyme F420-(gamma-Glu)(n); Xref=Rhea:RHEA:56092, Rhea:RHEA-COMP:12939, Rhea:RHEA-COMP:14378, ChEBI:CHEBI:15378, ChEBI:CHEBI:57977, ChEBI:CHEBI:57991, ChEBI:CHEBI:133980, ChEBI:CHEBI:139511; Evidence={ECO:0000269|PubMed:27364382}; |
| Biophysicochemical properties: | |
Kinetic parameters: KM=8.0 uM for biliverdin {ECO:0000269|PubMed:27364382}; Note=kcat is 0.072 sec(-1). {ECO:0000269|PubMed:27364382}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:27364382}. |
| Subcellular location: | |
Cell surface {ECO:0000305|PubMed:27364382}. Secreted {ECO:0000305|PubMed:27364382}. |
| Similarity: | |
Belongs to the F420H(2)-dependent biliverdin reductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.