UniProt functional annotation for P03960



	UniProt functional annotation for P03960

UniProt code: P03960.

Organism: Escherichia coli (strain K12).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.

Function: Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm (PubMed:2849541, PubMed:8499455, PubMed:23930894). This subunit is responsible for energy coupling to the transport system (PubMed:16354672). {ECO:0000269|PubMed:16354672, ECO:0000269|PubMed:23930894, ECO:0000269|PubMed:2849541, ECO:0000269|PubMed:8499455}.

Catalytic activity: Reaction=ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate; Xref=Rhea:RHEA:16777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.6; Evidence={ECO:0000255|HAMAP- Rule:MF_00285, ECO:0000269|PubMed:2849541};

Activity regulation: ATPase activity is inhibited by vanadate, fluorescein isothiocyanate, N,N'-dicyclohexylcarbodiimide and N- ethylmaleimide. {ECO:0000269|PubMed:2849541}.

Subunit: The system is composed of three essential subunits: KdpA, KdpB and KdpC (PubMed:2849541, PubMed:9858692). The complex also contains KdpF, a small non-essential subunit (PubMed:10608856). The KdpFABC complex exists as a dimer above concentrations of 30-50 nM, whereas the complex exists as a functional monomer at lower concentrations (PubMed:18298081). {ECO:0000269|PubMed:10608856, ECO:0000269|PubMed:18298081, ECO:0000269|PubMed:2849541, ECO:0000269|PubMed:9858692}.

Subcellular location: Cell inner membrane {ECO:0000255|HAMAP- Rule:MF_00285, ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2849541}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00285, ECO:0000269|PubMed:15919996}.

Induction: Transcriptionally regulated by the KdpD/KdpE two-component regulatory system. {ECO:0000269|PubMed:1532387}.

Similarity: Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. {ECO:0000255|HAMAP-Rule:MF_00285}.

Annotations taken from UniProtKB at the EBI.


Organism:		Escherichia coli (strain K12).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.



Function:		Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm (PubMed:2849541, PubMed:8499455, PubMed:23930894). This subunit is responsible for energy coupling to the transport system (PubMed:16354672). {ECO:0000269\|PubMed:16354672, ECO:0000269\|PubMed:23930894, ECO:0000269\|PubMed:2849541, ECO:0000269\|PubMed:8499455}.


Catalytic activity:		Reaction=ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate; Xref=Rhea:RHEA:16777, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.2.2.6; Evidence={ECO:0000255\|HAMAP- Rule:MF_00285, ECO:0000269\|PubMed:2849541};
Activity regulation:		ATPase activity is inhibited by vanadate, fluorescein isothiocyanate, N,N'-dicyclohexylcarbodiimide and N- ethylmaleimide. {ECO:0000269\|PubMed:2849541}.
Subunit:		The system is composed of three essential subunits: KdpA, KdpB and KdpC (PubMed:2849541, PubMed:9858692). The complex also contains KdpF, a small non-essential subunit (PubMed:10608856). The KdpFABC complex exists as a dimer above concentrations of 30-50 nM, whereas the complex exists as a functional monomer at lower concentrations (PubMed:18298081). {ECO:0000269\|PubMed:10608856, ECO:0000269\|PubMed:18298081, ECO:0000269\|PubMed:2849541, ECO:0000269\|PubMed:9858692}.
Subcellular location:		Cell inner membrane {ECO:0000255\|HAMAP- Rule:MF_00285, ECO:0000269\|PubMed:15919996, ECO:0000269\|PubMed:2849541}; Multi-pass membrane protein {ECO:0000255\|HAMAP-Rule:MF_00285, ECO:0000269\|PubMed:15919996}.
Induction:		Transcriptionally regulated by the KdpD/KdpE two-component regulatory system. {ECO:0000269\|PubMed:1532387}.
Similarity:		Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. {ECO:0000255\|HAMAP-Rule:MF_00285}.