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PDBsum entry 200d
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References listed in PDB file
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Key reference
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Title
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Stable loop in the crystal structure of the intercalated four-Stranded cytosine-Rich metazoan telomere.
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Authors
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C.Kang,
I.Berger,
C.Lockshin,
R.Ratliff,
R.Moyzis,
A.Rich,
A.Rich.
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Ref.
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Proc Natl Acad Sci U S A, 1995,
92,
3874-3878.
[DOI no: ]
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PubMed id
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Abstract
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In most metazoans, the telomeric cytosine-rich strand repeating sequence is
d(TAACCC). The crystal structure of this sequence was solved to 1.9-A
resolution. Four strands associate via the cytosine-containing parts to form a
four-stranded intercalated structure held together by C.C+ hydrogen bonds. The
base-paired strands are parallel to each other, and the two duplexes are
intercalated into each other in opposite orientations. One TAA end forms a
highly stabilized loop with the 5' thymine Hoogsteen-base-paired to the third
adenine. The 5' end of this loop is in close proximity to the 3' end of one of
the other intercalated cytosine strands. Instead of being entirely in a DNA
duplex, this structure suggests the possibility of an alternative conformation
for the cytosine-rich telomere strands.
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Headers
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