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UniProt functional annotation for Q7YZS9 | ||
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| UniProt code: Q7YZS9. |
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| Organism: | |
Conus virgo (Virgin cone). |
| Taxonomy: | |
Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Virgiconus. |
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| Function: | |
Kappa-conotoxins bind and inhibit voltage-gated potassium channels. This toxin inhibits the mammalian potassium channels Kv1.1/KCNA1 and Kv1.3/KCNA3. {ECO:0000269|PubMed:12893060}. |
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| Subcellular location: | |
Secreted {ECO:0000269|PubMed:12893060}. |
| Tissue specificity: | |
Expressed by the venom duct. {ECO:0000305|PubMed:12893060}. |
| Domain: | |
The cysteine framework is XI (C-C-CC-CC-C-C). {ECO:0000305}. |
| Ptm: | |
Contains 4 disulfide bonds. Here are reported disulfide bonds proposed in [PubMed:16268797], even if the connectivity known for the framework XI is I-IV, II-VI, III-VII, V-VIII. |
| Mass spectrometry: | |
Mass=3933.3; Method=Electrospray; Evidence={ECO:0000269|PubMed:12893060}; |
| Miscellaneous: | |
This toxin has no effects on Kv1.2/KCNA2, Kv11/KCNH, and Kir2.1/KCNJ2 potassium channels, and on Nav1.5/SCN5A sodium channels. {ECO:0000305|PubMed:12893060}. |
| Similarity: | |
Belongs to the conotoxin I2 superfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.