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UniProt functional annotation for O34777 | ||
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| UniProt code: O34777. |
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| Organism: | |
Bacillus subtilis (strain 168). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. |
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| Function: | |
Organic peroxide sensor. Represses the expression of the peroxide-inducible gene ohrA by cooperative binding to two inverted repeat elements. {ECO:0000269|PubMed:11418552}. |
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| Activity regulation: | |
Inactivated by oxidation of Cys-15 to a sulfenic acid. |
| Subunit: | |
Homodimer. |
| Subcellular location: | |
Cytoplasm. |
| Ptm: | |
Cys-15 is oxidized by organic peroxides to cysteine sulfenic acid (Cys-SOH). This can react with the alpha-amido of the following residue to form the sulfenamide cross-link. Oxidation or cross-linking results in the loss of DNA-binding activity and the inactivation of repressor function. Both the cysteine sulfenic acid and the sulfenamide cross- link can react with free cysteine or bacillithiol to form mixed disulfides. Further reduction of OhrR by free sulfhydryl compounds restores repressor activity. {ECO:0000269|PubMed:11983871}. |
Annotations taken from UniProtKB at the EBI.