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UniProt functional annotation for P04850 | ||
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| UniProt code: P04850. |
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| Organism: | |
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5). |
| Taxonomy: | |
Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; Monjiviricetes; Mononegavirales; Paramyxoviridae; Rubulavirinae; Orthorubulavirus; Mammalian orthorubulavirus 5. |
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| Function: | |
Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity). {ECO:0000250}. |
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| Function: | |
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins. {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha- (2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.; EC=3.2.1.18; |
| Subcellular location: | |
Virion membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Host cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Similarity: | |
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.