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UniProt functional annotation for P20429 | ||
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| UniProt code: P20429. |
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| Organism: | |
Bacillus subtilis (strain 168). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. |
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| Function: | |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. {ECO:0000269|PubMed:18289874}. |
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| Catalytic activity: | |
Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:11128, Rhea:RHEA- COMP:11129, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:83400; EC=2.7.7.6; Evidence={ECO:0000255|HAMAP-Rule:MF_00059, ECO:0000269|PubMed:6802805}; |
| Subunit: | |
Homodimer. RNAP is composed of a core of 2 alpha, a beta and a beta' subunit. The core is associated with a delta subunit, and at least one of epsilon or omega (PubMed:6802805, PubMed:18289874, PubMed:21710567). When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription (PubMed:18289874). {ECO:0000255|HAMAP-Rule:MF_00059, ECO:0000269|PubMed:18289874, ECO:0000269|PubMed:21710567, ECO:0000269|PubMed:6802805}. |
| Domain: | |
The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. {ECO:0000255|HAMAP-Rule:MF_00059}. |
| Similarity: | |
Belongs to the RNA polymerase alpha chain family. {ECO:0000255|HAMAP-Rule:MF_00059}. |
Annotations taken from UniProtKB at the EBI.