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UniProt functional annotation for Q9H8F0 | ||
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| UniProt codes: Q9H2X3, Q9H8F0. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates. {ECO:0000269|PubMed:11257134}. |
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| Function: | |
(Microbial infection) Acts as an attachment receptor for Ebolavirus. {ECO:0000269|PubMed:12050398, ECO:0000269|PubMed:12502850}. |
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| Function: | |
(Microbial infection) Acts as an attachment receptor for Hepatitis C virus. {ECO:0000269|PubMed:15371595, ECO:0000269|PubMed:16816373}. |
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| Function: | |
(Microbial infection) Acts as an attachment receptor for HIV- 1. {ECO:0000269|PubMed:12502850, ECO:0000269|PubMed:21203928}. |
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| Function: | |
(Microbial infection) Acts as an attachment receptor for Human coronavirus 229E. {ECO:0000269|PubMed:17037540}. |
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| Function: | |
(Microbial infection) Acts as an attachment receptor for Human cytomegalovirus/HHV-5. {ECO:0000269|PubMed:12433371}. |
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| Function: | |
(Microbial infection) Acts as an attachment receptor for Influenzavirus. {ECO:0000269|PubMed:21191006}. |
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| Function: | |
(Microbial infection) Acts as an attachment receptor for SARS-CoV. {ECO:0000269|PubMed:15479853}. |
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| Function: | |
(Microbial infection) Acts as an attachment receptor for West-nile virus. {ECO:0000269|PubMed:15479853}. |
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| Function: | |
(Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus. {ECO:0000269|PubMed:24623090}. |
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| Function: | |
(Microbial infection) Acts as an attachment receptor for Marburg virus glycoprotein. {ECO:0000269|PubMed:15479853}. |
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| Function: | |
(Microbial infection) Recognition of M.bovis by dendritic cells may occur partially via this molecule. {ECO:0000269|PubMed:21277928}. |
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| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:11384997, ECO:0000269|PubMed:11739956}. |
| Subunit: | |
(Microbial infection) Interacts with ebola virus glycoprotein (PubMed:12050398, PubMed:12502850). {ECO:0000269|PubMed:12050398, ECO:0000269|PubMed:12502850}. |
| Subunit: | |
(Microbial infection) Interacts with hepatitis C virus E1 and E2 protein (PubMed:15371595, PubMed:16816373). {ECO:0000269|PubMed:15371595, ECO:0000269|PubMed:16816373}. |
| Subunit: | |
(Microbial infection) Interacts with HIV-1 gp120 (PubMed:21277928, PubMed:12502850). {ECO:0000269|PubMed:12502850, ECO:0000269|PubMed:21277928}. |
| Subunit: | |
(Microbial infection) Interacts with human coronavirus 229E spike glycoprotein. {ECO:0000269|PubMed:17037540}. |
| Subunit: | |
(Microbial infection) Interacts with human cytomegalovirus/HHV-5 gB protein. {ECO:0000269|PubMed:12433371}. |
| Subunit: | |
(Microbial infection) Interacts with influenzavirus hemagglutinin. {ECO:0000269|PubMed:21191006}. |
| Subunit: | |
(Microbial infection) Interacts with SARS-CoV spike glycoprotein. {ECO:0000269|PubMed:15479853}. |
| Subunit: | |
(Microbial infection) Interacts with west-nile virus envelope protein E. {ECO:0000269|PubMed:16415006}. |
| Subunit: | |
(Microbial infection) Interacts with Japanese encephalitis virus E protein. {ECO:0000269|PubMed:24623090}. |
| Subunit: | |
(Microbial infection) Interacts with Marburg virus glycoprotein. {ECO:0000269|PubMed:15479853}. |
| Subunit: | |
(Microbial infection) Interacts with M.bovis LprG. {ECO:0000269|PubMed:21203928}. |
| Subcellular location: | |
[Isoform 1]: Cell membrane {ECO:0000305}; Single- pass type II membrane protein {ECO:0000305}. |
| Subcellular location: | |
[Isoform 2]: Cell membrane {ECO:0000305}; Single- pass type II membrane protein {ECO:0000305}. |
| Subcellular location: | |
[Isoform 3]: Cell membrane {ECO:0000305}; Single- pass type II membrane protein {ECO:0000305}. |
| Subcellular location: | |
[Isoform 5]: Secreted {ECO:0000305}. |
| Subcellular location: | |
[Isoform 6]: Secreted {ECO:0000305}. |
| Subcellular location: | |
[Isoform 7]: Secreted {ECO:0000305}. |
| Subcellular location: | |
[Isoform 10]: Secreted {ECO:0000305}. |
| Tissue specificity: | |
Predominantly highly expressed in liver sinusoidal endothelial cells and in lymph node. Found in placental endothelium but not in macrophages. Expressed in type II alveolar cells and lung endothelial cells. {ECO:0000269|PubMed:11226297, ECO:0000269|PubMed:11257134, ECO:0000269|PubMed:15496474}. |
| Domain: | |
The tandem repeat domain, also called neck domain, mediates oligomerization. |
| Polymorphism: | |
The number of repeats in the tandem repeat domain is shown to vary between 3 and 9 per allele thus contributing to a further variability in addition to alternative splicing. The shown 7 repeat- containing form has been shown to be the most frequent one (53.9%) in a study with 350 Caucasian individuals. |
| Miscellaneous: | |
In vitro, is a receptor for HIV-1 and transmits HIV-1 to permissive T-cells. |
| Miscellaneous: | |
[Isoform 2]: May be due to intron retention. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform 6]: May be due to intron retention. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform 8]: Non-canonical intron-exon splice junction. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform 10]: May be due to intron retention. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAR04559.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.