UniProt functional annotation for P9WJA3



	UniProt functional annotation for P9WJA3

UniProt code: P9WJA3.

Organism: Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).

Taxonomy: Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.

Function: Unlike some other CBS-domain containing proteins does not seem to bind AMP.

Subunit: Homodimer. Forms an SDS-resistant dimer that requires Cys-136 for SDS-resistance. {ECO:0000269|PubMed:16511097, ECO:0000269|PubMed:18640126}.

Subcellular location: Secreted {ECO:0000269|PubMed:18640126}. Note=Not seen to be associated with the cell wall.

Induction: A member of the dormancy regulon. Induced in response to reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and carbon monoxide (CO). It is hoped that this regulon will give insight into the latent, or dormant phase of infection. Following a shift from stationary to anaerobic growth this protein is not seen to not be further induced (at protein level). Induced in mouse lungs at the same time that adaptive host immunity induces bacterial growth arrest; induction is dependent on interferon gamma. {ECO:0000269|PubMed:11416222, ECO:0000269|PubMed:12057942, ECO:0000269|PubMed:12506197, ECO:0000269|PubMed:12953092, ECO:0000269|PubMed:18400743, ECO:0000269|PubMed:18474359}.

Biotechnology: In plasmid DNA-vaccinated mice, subsequent challenge with this protein induces positive levels of antigen-specific IFN-gamma and IL-2, indicating this might be a good vaccine candidate. {ECO:0000269|PubMed:17145953}.

Miscellaneous: Has been detected extracellularly but no signal sequence is predicted by bioinformatic programs.

Annotations taken from UniProtKB at the EBI.


Organism:		Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
Taxonomy:		Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.



Function:		Unlike some other CBS-domain containing proteins does not seem to bind AMP.


Subunit:		Homodimer. Forms an SDS-resistant dimer that requires Cys-136 for SDS-resistance. {ECO:0000269\|PubMed:16511097, ECO:0000269\|PubMed:18640126}.
Subcellular location:		Secreted {ECO:0000269\|PubMed:18640126}. Note=Not seen to be associated with the cell wall.
Induction:		A member of the dormancy regulon. Induced in response to reduced oxygen tension (hypoxia), low levels of nitric oxide (NO) and carbon monoxide (CO). It is hoped that this regulon will give insight into the latent, or dormant phase of infection. Following a shift from stationary to anaerobic growth this protein is not seen to not be further induced (at protein level). Induced in mouse lungs at the same time that adaptive host immunity induces bacterial growth arrest; induction is dependent on interferon gamma. {ECO:0000269\|PubMed:11416222, ECO:0000269\|PubMed:12057942, ECO:0000269\|PubMed:12506197, ECO:0000269\|PubMed:12953092, ECO:0000269\|PubMed:18400743, ECO:0000269\|PubMed:18474359}.
Biotechnology:		In plasmid DNA-vaccinated mice, subsequent challenge with this protein induces positive levels of antigen-specific IFN-gamma and IL-2, indicating this might be a good vaccine candidate. {ECO:0000269\|PubMed:17145953}.
Miscellaneous:		Has been detected extracellularly but no signal sequence is predicted by bioinformatic programs.