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UniProt functional annotation for Q9BYN0 | ||
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| UniProt code: Q9BYN0. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase. {ECO:0000269|PubMed:15448164, ECO:0000269|PubMed:15590625}. |
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| Catalytic activity: | |
Reaction=[peroxiredoxin]-S-hydroxy-S-oxy-L-cysteine + [protein]-dithiol + ATP = [peroxiredoxin]-S-hydroxy-L-cysteine + [protein]-disulfide + ADP + H(+) + phosphate; Xref=Rhea:RHEA:17545, Rhea:RHEA-COMP:10593, Rhea:RHEA-COMP:10594, Rhea:RHEA-COMP:13681, Rhea:RHEA-COMP:14051, ChEBI:CHEBI:15378, ChEBI:CHEBI:29950, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:50058, ChEBI:CHEBI:61967, ChEBI:CHEBI:61973, ChEBI:CHEBI:456216; EC=1.8.98.2; |
| Cofactor: | |
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:15448164}. |
| Tissue specificity: | |
Widely expressed with highest levels in kidney, lung, spleen and thymus. {ECO:0000269|PubMed:15448164}. |
| Similarity: | |
Belongs to the sulfiredoxin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.