UniProt functional annotation for Q29411



	UniProt functional annotation for Q29411

UniProt code: Q29411.

Organism: Sus scrofa (Pig).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.

Function: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia- induced injury, inflammation and epithelial apoptosis in lung (By similarity). Stimulates migration and adhesion of cultured vascular smooth muscle cells. {ECO:0000250, ECO:0000269|PubMed:12799184}.

Subunit: Monomer. {ECO:0000250}.

Subcellular location: Secreted, extracellular space {ECO:0000269|PubMed:3086326, ECO:0000269|PubMed:7768902}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.

Tissue specificity: Detected in smooth muscle cells in atherosclerotic plaques. Detected in regions of vascular occlusion in the aorta. {ECO:0000269|PubMed:12799184, ECO:0000269|PubMed:7768902}.

Induction: Up-regulated in cultured aortic smooth muscle cells upon transition to a nodular, multilayered culture. {ECO:0000269|PubMed:7768902}.

Similarity: Belongs to the glycosyl hydrolase 18 family. {ECO:0000305}.

Sequence caution: Sequence=AAV30548.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Sus scrofa (Pig).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.



Function:		Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia- induced injury, inflammation and epithelial apoptosis in lung (By similarity). Stimulates migration and adhesion of cultured vascular smooth muscle cells. {ECO:0000250, ECO:0000269\|PubMed:12799184}.


Subunit:		Monomer. {ECO:0000250}.
Subcellular location:		Secreted, extracellular space {ECO:0000269\|PubMed:3086326, ECO:0000269\|PubMed:7768902}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
Tissue specificity:		Detected in smooth muscle cells in atherosclerotic plaques. Detected in regions of vascular occlusion in the aorta. {ECO:0000269\|PubMed:12799184, ECO:0000269\|PubMed:7768902}.
Induction:		Up-regulated in cultured aortic smooth muscle cells upon transition to a nodular, multilayered culture. {ECO:0000269\|PubMed:7768902}.
Similarity:		Belongs to the glycosyl hydrolase 18 family. {ECO:0000305}.
Sequence caution:		Sequence=AAV30548.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305};