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UniProt functional annotation for P10724 | ||
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| UniProt code: P10724. |
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| Organism: | |
Geobacillus stearothermophilus (Bacillus stearothermophilus). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Geobacillus. |
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| Function: | |
Catalyzes the interconversion of L-alanine and D-alanine. Also weakly active on serine. {ECO:0000269|PubMed:10502689, ECO:0000269|PubMed:12203980}. |
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| Catalytic activity: | |
Reaction=L-alanine = D-alanine; Xref=Rhea:RHEA:20249, ChEBI:CHEBI:57416, ChEBI:CHEBI:57972; EC=5.1.1.1; Evidence={ECO:0000255|HAMAP-Rule:MF_01201, ECO:0000269|PubMed:10079072, ECO:0000269|PubMed:12203980, ECO:0000269|PubMed:12741835}; |
| Cofactor: | |
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000255|HAMAP-Rule:MF_01201, ECO:0000269|PubMed:10079072, ECO:0000269|PubMed:11886871, ECO:0000269|PubMed:12741835, ECO:0000269|PubMed:15807525, ECO:0000269|PubMed:9063881, ECO:0000269|PubMed:9671513}; |
| Activity regulation: | |
Inhibited by acetate and propionate. Irreversibly inhibited by cycloserine. {ECO:0000269|PubMed:10079072, ECO:0000269|PubMed:12741835, ECO:0000269|PubMed:15807525}. |
| Pathway: | |
Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_01201}. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:10079072, ECO:0000269|PubMed:15807525, ECO:0000269|PubMed:9063881, ECO:0000269|PubMed:9671513, ECO:0000269|Ref.10}. |
| Similarity: | |
Belongs to the alanine racemase family. {ECO:0000255|HAMAP- Rule:MF_01201}. |
Annotations taken from UniProtKB at the EBI.