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UniProt functional annotation for P36952 | ||
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| UniProt code: P36952. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
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| Subunit: | |
Interacts with IRF6. {ECO:0000269|PubMed:16049006}. |
| Subcellular location: | |
Secreted, extracellular space. |
| Tissue specificity: | |
Normal mammary epithelial cells. |
| Similarity: | |
Belongs to the serpin family. Ov-serpin subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.