 |
PDBsum entry 1xnq
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
234 a.a.
|
|
|
|
|
|
|
|
|
|
|
206 a.a.
|
|
|
|
|
|
|
|
|
|
|
208 a.a.
|
|
|
|
|
|
|
|
|
|
|
150 a.a.
|
|
|
|
|
|
|
|
|
|
|
101 a.a.
|
|
|
|
|
|
|
|
|
|
|
155 a.a.
|
|
|
|
|
|
|
|
|
|
|
138 a.a.
|
|
|
|
|
|
|
|
|
|
|
127 a.a.
|
|
|
|
|
|
|
|
|
|
|
98 a.a.
|
|
|
|
|
|
|
|
|
|
|
119 a.a.
|
|
|
|
|
|
|
|
|
|
|
124 a.a.
|
|
|
|
|
|
|
|
|
|
|
125 a.a.
|
|
|
|
|
|
|
|
|
|
|
60 a.a.
|
|
|
|
|
|
|
|
|
|
|
88 a.a.
|
|
|
|
|
|
|
|
|
|
|
83 a.a.
|
|
|
|
|
|
|
|
|
|
|
104 a.a.
|
|
|
|
|
|
|
|
|
|
|
73 a.a.
|
|
|
|
|
|
|
|
|
|
|
80 a.a.
|
|
|
|
|
|
|
|
|
|
|
99 a.a.
|
|
|
|
|
|
|
|
|
|
|
24 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
References listed in PDB file
|
|
|
Key reference
|
|
|
Title
|
|
Structure of a purine-Purine wobble base pair in the decoding center of the ribosome.
|
|
|
Authors
|
|
F.V.Murphy,
V.Ramakrishnan.
|
|
|
Ref.
|
|
Nat Struct Mol Biol, 2004,
11,
1251-1252.
[DOI no: ]
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
Here we report the crystal structures of I.C and I.A wobble base pairs in the
context of the ribosomal decoding center, clearly showing that the I.A base pair
is of an I(anti).A(anti) conformation, as predicted by Crick. Additionally, the
structures enable the observation of changes in the anticodon to allow
purine-purine base pairing, the 'widest' base pair geometry allowed in the
wobble position.
|
|
|
|
|
|
|
|
Figure 1.
Figure 1. Cartoon structures of the I  C
and I A
base pairs.
|
|
Figure 2.
Figure 2. Details of base pairs. (a) I C
base pair (I, green; C, yellow) with 2F[o] - F[c] map contoured
to 1.6  .
(b) I A
base pair (I, green; A, cyan) with 2F[o] - F[c] map contoured to
1.6 .
(c) I C
base pair with hydrogen bonds as dashed lines. (d) I A
base pairs (both anti-anti and syn-anti).
|
|
|
|
|
|
The above figures are
reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Mol Biol
(2004,
11,
1251-1252)
copyright 2004.
|
|
|
|
|
|
|
