PDBsum entry 1xdh

Hydrolase/hydrolase inhibitor

PDB id: 1xdh

Contents

Protein chains

329 a.a. *

Ligands

IVA-VAL-VAL-STA-ALA-STA ×2

Waters ×736

* Residue conservation analysis

PDB id:

1xdh

Name:

Hydrolase/hydrolase inhibitor

Title:

Structure of plasmepsin ii in complex with pepstatin a

Structure:

Plasmepsin 2. Chain: a, b. Synonym: aspartic hemoglobinase ii, pfapd. Pepstatin. Chain: c, d. Engineered: yes

Source:

Plasmodium falciparum. Malaria parasite p. Falciparum. Organism_taxid: 5833. Synthetic: yes. Streptomyces argenteolus subsp. Toyonakensis. Organism_taxid: 285516

Biol. unit:

Dimer (from PQS)

Resolution:

1.70Å R-factor: 0.215 R-free: 0.237

Authors:

L.Prade

Key ref:

L.Prade Structure of plasmepsin ii in complex with pepstatin a. To be published, .

Date:

06-Sep-04 Release date: 23-Aug-05

Protein chains

P46925  (PLM2_PLAFX) -  Plasmepsin II from Plasmodium falciparum (isolate HB3)

Seq: 453 a.a.

Struc: 329 a.a.

Enzyme reactions

• Enzyme class: E.C.3.4.23.39 - plasmepsin Ii.
• Reaction: Hydrolysis of the bonds linking certain hydrophobic residues in hemoglobin or globin. Also cleaves small molecules substrates such as Ala-Leu-Glu-Arg-Thr-Phe-|-Phe(NO(2))-Ser-Phe-Pro-Thr.