 |
PDBsum entry 1xcs
|
|
|
|
References listed in PDB file
|
 |
|
Key reference
|
|
|
Title
|
|
Variable role of ions in two drug intercalation complexes of DNA.
|
|
|
Authors
|
|
N.Valls,
R.A.Steiner,
G.Wright,
G.N.Murshudov,
J.A.Subirana.
|
|
|
Ref.
|
|
J Biol Inorg Chem, 2005,
10,
476-482.
|
|
|
PubMed id
|
|
|
|
|
|
Abstract
|
|
|
The crystal structures of the hexamer duplex d(CGTACG)(2) complexed with the
intercalating anthraquinone derivative
1,5-bis[3-(diethylamino)propionamido]anthracene-9,10-dione and the acridine
derivative 9-acridinyl tetralysine have been solved at 2.0- and 1.4-A
resolution, respectively. In both cases, the drugs adopt multiple orientations
within a large DNA cavity constituted by two groups of four approximately
coplanar bases. Cations play a pivotal role in the crystal structure. Both
complexes crystallise in the presence of Co(2+), Ba(2+) and Na(+) ions. They
reveal at least two different types of coordination environments: (1) specific
sites for Co(2+) interacting with N7 of guanine; (2) a central ionic site formed
by four phosphate groups, which can be occupied by different ions. One more
ionic site that is not always occupied by ions is also visible in the electron
density map. All of them play a role in the crystal structure.
|
|
|
|
|
|
|
|
Headers
|
|
|
|
|
|
