UniProt functional annotation for Q92859



	UniProt functional annotation for Q92859

UniProt code: Q92859.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269|PubMed:21149453}.

Subunit: Interacts with MYO10 (By similarity). Interacts with RGMA and RGMB. Interacts with BMP2, BMP4, BMP6, and BMP7. {ECO:0000250, ECO:0000269|PubMed:18287331, ECO:0000269|PubMed:21149453}.

Subcellular location: Cell membrane; Single-pass type I membrane protein.

Tissue specificity: Widely expressed and also in cancer cell lines.

Domain: The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules. {ECO:0000250}.

Miscellaneous: Knockdown of NEO1 in C2C12 cells results in the enhancement of the BMP-2-induced processes of osteoblastic differentiation and phosphorylation of Smad1, Smad5, and Smad8. Conversely, overexpression suppresses these processes.

Similarity: Belongs to the immunoglobulin superfamily. DCC family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response. {ECO:0000269\|PubMed:21149453}.


Subunit:		Interacts with MYO10 (By similarity). Interacts with RGMA and RGMB. Interacts with BMP2, BMP4, BMP6, and BMP7. {ECO:0000250, ECO:0000269\|PubMed:18287331, ECO:0000269\|PubMed:21149453}.
Subcellular location:		Cell membrane; Single-pass type I membrane protein.
Tissue specificity:		Widely expressed and also in cancer cell lines.
Domain:		The Fibronectin repeats 5 and 6 mediate interaction with RGM family molecules. {ECO:0000250}.
Miscellaneous:		Knockdown of NEO1 in C2C12 cells results in the enhancement of the BMP-2-induced processes of osteoblastic differentiation and phosphorylation of Smad1, Smad5, and Smad8. Conversely, overexpression suppresses these processes.
Similarity:		Belongs to the immunoglobulin superfamily. DCC family. {ECO:0000305}.