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UniProt functional annotation for Q9DC04 | ||
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| UniProt code: Q9DC04. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein- mediated release of inositol phosphates and activation of MAP kinases. {ECO:0000269|PubMed:11301003, ECO:0000269|PubMed:12210723}. |
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| Subunit: | |
Binds the GNB1-GNG2 heterodimer (By similarity). Binds EFNB1 and EFNB2. {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P49796}; Peripheral membrane protein {ECO:0000250|UniProtKB:P49796}; Cytoplasmic side {ECO:0000250|UniProtKB:P49796}. Note=Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear. {ECO:0000250|UniProtKB:P49796}. |
| Subcellular location: | |
[Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11301003}. |
| Subcellular location: | |
[Isoform 3]: Nucleus {ECO:0000269|PubMed:12210723}. |
| Subcellular location: | |
[Isoform 4]: Nucleus {ECO:0000305}. |
| Tissue specificity: | |
Detected in embryos from E8.5-16.5 in cortical ventricular zone, dorsal root ganglia and cerebellar primordia. Isoform 3 is detected in testis and in spermatocytes from newborn mice. Levels increase and reach a maximum after 21 days; after this they decrease again. Long isoforms are widely expressed. {ECO:0000269|PubMed:11034339}. |
| Ptm: | |
Phosphorylated by cyclic GMP-dependent protein kinase. {ECO:0000250}. |
| Ptm: | |
ISGylated. {ECO:0000250}. |
| Miscellaneous: | |
[Isoform 3]: Nuclear. {ECO:0000269|PubMed:12210723}. |
Annotations taken from UniProtKB at the EBI.