|
|
||
|
|
|
|
|
UniProt functional annotation for Q15646 | ||
|
|
|
|
|
|
||
| UniProt code: Q15646. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L. {ECO:0000269|PubMed:18931074, ECO:0000269|PubMed:20074559, ECO:0000269|PubMed:9826176}. |
|
||
| Subunit: | |
Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not require the presence of thyroid hormone for its interaction. Binds MBD1. {ECO:0000269|PubMed:14728690}. |
| Subcellular location: | |
[Isoform p56]: Nucleus, nucleolus. Cytoplasm. |
| Subcellular location: | |
[Isoform p30]: Cytoplasm. |
| Tissue specificity: | |
Expressed in most tissues, with the highest levels in primary blood Leukocytes and other hematopoietic system tissues, colon, stomach and to some extent in testis. |
| Induction: | |
By type I interferon (IFN) and viruses. {ECO:0000269|PubMed:19203244, ECO:0000269|PubMed:20074559}. |
| Domain: | |
The ubiquitin-like domains are essential for its antiviral activity. |
| Miscellaneous: | |
[Isoform 3]: Has antiviral activity against RNA viruses. {ECO:0000305}. |
| Similarity: | |
Belongs to the 2-5A synthase family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=AAC41733.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.