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UniProt functional annotation for P00798 | ||
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| UniProt code: P00798. |
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| Organism: | |
Penicillium janthinellum (Penicillium vitale). |
| Taxonomy: | |
Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium. |
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| Function: | |
Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but can also activate trypsinogen and hydrolyze the B chain of insulin between positions 'Gly-20' and 'Glu-21'. {ECO:0000269|PubMed:4946839}. |
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| Catalytic activity: | |
Reaction=Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1', but also cleaving 20-Gly-|-Glu-21 in the B chain of insulin. Clots milk, and activates trypsinogen.; EC=3.4.23.20; Evidence={ECO:0000269|PubMed:4946839}; |
| Subunit: | |
Monomer. {ECO:0000250|UniProtKB:Q12567}. |
| Subcellular location: | |
Secreted {ECO:0000250|UniProtKB:Q01972}. |
| Similarity: | |
Belongs to the peptidase A1 family. {ECO:0000255|PROSITE- ProRule:PRU01103}. |
Annotations taken from UniProtKB at the EBI.